Tyrosine-protein kinase BLK

 Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene.^[5][6] It is of the Src family of tyrosine kinases.

BLK
Identifiers
Aliases	BLK, MODY11, BLK proto-oncogene, Src family tyrosine kinase
External IDs	OMIM: 191305 MGI: 88169 HomoloGene: 1297 GeneCards: BLK
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p23.1 Start 11,486,894 bp[1] End 11,564,599 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 33.25 cM Start 63,372,836 bp[2] End 63,417,037 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • GO:0001948 protein binding • protein tyrosine kinase activity • receptor binding • ATP binding Cellular component • membrane • extrinsic component of cytoplasmic side of plasma membrane • cell membrane • cytosol Biological process • B cell receptor signaling pathway • cell differentiation • GO:0007243 intracellular signal transduction • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • protein phosphorylation • regulation of cell proliferation • peptidyl-tyrosine autophosphorylation • innate immune system • positive regulation of insulin secretion • cell migration • regulation of B cell receptor signaling pathway • peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	640	12143
Ensembl	ENSG00000136573 ENSG00000285369	ENSMUSG00000014453
UniProt	P51451	P16277
RefSeq (mRNA)	NM_001715 NM_001330465	NM_007549
RefSeq (protein)	NP_001317394 NP_001706	NP_031575
Location (UCSC)	Chr 8: 11.49 – 11.56 Mb	Chr 14: 63.37 – 63.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

InteractionsEdit

The tyrosine-protein kinase BLK has been shown to interact with UBE3A.^[7]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.