TICAM2

 TIR domain-containing adapter molecule 2 is a protein that in humans is encoded by the TICAM2 gene.^[4]

TICAM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M1W
Identifiers
Aliases	TICAM2, MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM, toll like receptor adaptor molecule 2
External IDs	OMIM: 608321 MGI: 3040056 HomoloGene: 11014 GeneCards: TICAM2
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q22.3 Start 115,578,650 bp[1] End 115,602,479 bp[1]
Gene ontology Molecular function • signal transducer activity • GO:0001948 protein binding Cellular component • cytoplasm • endosome • late endosome • Golgi apparatus • early endosome membrane • membrane • late endosome membrane • cell membrane • early endosome • endoplasmic reticulum • endosome membrane • secretory granule membrane Biological process • toll-like receptor 4 signaling pathway • negative regulation of chemokine (C-C motif) ligand 5 production • immune system process • TRAM-dependent toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • positive regulation of toll-like receptor 4 signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • inflammatory response • cellular response to lipopolysaccharide • I-kappaB kinase/NF-kappaB signaling • negative regulation of toll-like receptor 4 signaling pathway • MyD88-independent toll-like receptor signaling pathway • signal transduction • GO:0060554, GO:0060555 necroptosis • apoptotic signaling pathway • negative regulation of MyD88-independent toll-like receptor signaling pathway • innate immune system • neutrophil degranulation • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of interleukin-18-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	353376	225471
Ensembl	ENSG00000243414	ENSMUSG00000056130
UniProt	Q86XR7	Q8BJQ4
RefSeq (mRNA)	NM_021649	NM_173394
RefSeq (protein)	NP_067681 NP_001157940 NP_001157941	NP_775570
Location (UCSC)	Chr 5: 115.58 – 115.6 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM]^[4]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.