3-oxo-5α-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.[4][5] It is one of three isozymes of 5α-reductase.
| SRD5A2 |
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| Identifiers |
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| Aliases | SRD5A2, entrez:6716, steroid 5 alpha-reductase 2 |
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| External IDs | OMIM: 607306 MGI: 2150380 HomoloGene: 37292 GeneCards: SRD5A2 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 2 (human)[1] |
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| | Band | 2p23.1 | Start | 31,522,480 bp[1] |
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| End | 31,580,938 bp[1] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • oxidoreductase activity, acting on the CH-CH group of donors
• sterol 5-alpha reductase activity
• cholestenone 5-alpha-reductase activity
• amide binding
• oxidoreductase activity
• 3-oxo-5-alpha-steroid 4-dehydrogenase activity
• testosterone dehydrogenase [NAD(P) activity]
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| Cellular component | • cytoplasm
• organelle membrane
• integral component of membrane
• membrane
• cell body fiber
• intracellular membrane-bounded organelle
• neuronal cell body
• endoplasmic reticulum
• endoplasmic reticulum membrane
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| Biological process | • cell differentiation
• male gonad development
• phthalate metabolic process
• biphenyl metabolic process
• response to organic cyclic compound
• lipid metabolism
• response to testosterone
• response to steroid hormone
• cell-cell signaling
• response to peptide hormone
• sex differentiation
• response to organic substance
• steroid catabolic process
• response to nutrient levels
• dibenzo-p-dioxin metabolic process
• hypothalamus development
• bone development
• hippocampus development
• oxidation-reduction process
• response to follicle-stimulating hormone
• response to drug
• androgen metabolic process
• steroid metabolic process
• androgen biosynthetic process
• male genitalia development
• female genitalia development
• progesterone metabolic process
• testosterone biosynthetic process
• steroid biosynthetic process
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 2: 31.52 – 31.58 Mb | n/a |
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| PubMed search | [2] | [3] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Steroid 5α-reductase catalyzes the conversion of the male sex hormone testosterone into the more potent androgen, dihydrotestosterone.
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).[5]
