SH2B2

 SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.^[5][6]

SH2B2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q2H
Identifiers
Aliases	SH2B2, APS, SH2B adaptor protein 2
External IDs	OMIM: 605300 MGI: 1345171 HomoloGene: 10309 GeneCards: SH2B2
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 102,285,091 bp[1] End 102,321,711 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 136,218,147 bp[2] End 136,246,556 bp[2]
Gene ontology Molecular function • JAK pathway signal transduction adaptor activity • GO:0001948 protein binding • signaling adaptor activity • transmembrane receptor protein tyrosine kinase adaptor activity • identical protein binding Cellular component • cytoplasm • cytosol • cell membrane • membrane • stress fiber • ruffle • actin filament Biological process • insulin receptor signaling pathway • blood coagulation • signal transduction • regulation of JAK-STAT cascade • positive regulation of signal transduction • GO:0007243 intracellular signal transduction • B-1 B cell homeostasis • nervous system development • cytokine-mediated signaling pathway • regulation of metabolic process • actin cytoskeleton organization • regulation of Ras protein signal transduction • regulation of immune response • antigen receptor-mediated signaling pathway • brown fat cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10603	23921
Ensembl	ENSG00000160999	ENSMUSG00000005057
UniProt	O14492	Q9JID9
RefSeq (mRNA)	NM_020979 NM_001359228 NM_001359229 NM_001359230 NM_001359231	NM_018825 NM_001302938 NM_001302939
RefSeq (protein)	NP_066189 NP_001346157 NP_001346158 NP_001346159 NP_001346160	NP_001289867 NP_001289868 NP_061295
Location (UCSC)	Chr 7: 102.29 – 102.32 Mb	Chr 5: 136.22 – 136.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.^[6]

InteractionsEdit

SH2B2 has been shown to interact with TrkA^[7] and Cbl gene.^[8][9]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.