NOS1AP

 Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a protein that in humans is encoded by the NOS1AP gene.^[3][4][5]

NOS1AP
Identifiers
Aliases	NOS1AP, 6330408P19Rik, CAPON, nitric oxide synthase 1 adaptor protein
External IDs	OMIM: 605551 HomoloGene: 136252 GeneCards: NOS1AP
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 162,069,691 bp[1] End 162,370,475 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • nitric-oxide synthase binding Cellular component • L-type voltage-gated calcium channel complex • cytosol • not the membrane • inward rectifier potassium channel complex • perinuclear region of cytoplasm • sarcolemma • cell nucleus • mitochondrion • caveola • Z disc • T-tubule • sarcoplasmic reticulum membrane • glutamatergic synapse Biological process • positive regulation of peptidyl-cysteine S-nitrosylation • regulation of cardiac muscle cell action potential • positive regulation of nitric oxide biosynthetic process • regulation of nitric-oxide synthase activity • positive regulation of delayed rectifier potassium channel activity • positive regulation of gene expression • positive regulation of nitric oxide mediated signal transduction • positive regulation of nitric-oxide synthase activity • regulation of high voltage-gated calcium channel activity • positive regulation of potassium ion transmembrane transport • regulation of heart rate by chemical signal • positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization • regulation of nitric oxide biosynthetic process • regulation of calcium ion transmembrane transport via high voltage-gated calcium channel • regulation of ventricular cardiac muscle cell membrane repolarization • postsynaptic actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9722	n/a
Ensembl	ENSG00000198929	n/a
UniProt	O75052	n/a
RefSeq (mRNA)	NM_014697 NM_001126060 NM_001164757	n/a
RefSeq (protein)	NP_001119532 NP_001158229 NP_055512	n/a
Location (UCSC)	Chr 1: 162.07 – 162.37 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins.^[5] NOS1AP polymorphisms has been associated with the QT interval length.^[6]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.