NOD1

 Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor that in humans is encoded by the NOD1 gene.^[5][6] It recognizes bacterial molecules and stimulates an immune reaction .^[7]

NOD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B1W, 2DBD, 2NSN, 2NZ7, 4E9M, 4JQW
Identifiers
Aliases	NOD1, CARD4, CLR7.1, NLRC1, nucleotide binding oligomerization domain containing 1
External IDs	OMIM: 605980 MGI: 1341839 HomoloGene: 4440 GeneCards: NOD1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.3 Start 30,424,527 bp[1] End 30,478,784 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B3 Start 54,923,949 bp[2] End 54,972,612 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • protein homodimerization activity • GO:0001948 protein binding • peptidoglycan binding • identical protein binding • cysteine-type endopeptidase activator activity involved in apoptotic process • CARD domain binding • ATP binding • GO:0032403 macromolecular complex binding Cellular component • cytoplasm • cytosol • membrane • cell membrane • basolateral plasma membrane • apical plasma membrane Biological process • regulation of apoptotic process • defense response • detection of biotic stimulus • GO:0007243 intracellular signal transduction • positive regulation of cell death • immune system process • positive regulation of JNK cascade • positive regulation of xenophagy • positive regulation of NIK/NF-kappaB signaling • cellular response to muramyl dipeptide • JNK cascade • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of dendritic cell antigen processing and presentation • positive regulation of nitric-oxide synthase activity • activation of MAPK activity • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • protein oligomerization • detection of bacterium • positive regulation of interleukin-1 beta production • positive regulation of ERK1 and ERK2 cascade • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of I-kappaB kinase/NF-kappaB signaling • inflammatory response • activation of cysteine-type endopeptidase activity involved in apoptotic process • nucleotide-binding oligomerization domain containing signaling pathway • signal transduction • positive regulation of stress-activated MAPK cascade • defense response to Gram-positive bacterium • apoptotic process • innate immune system • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10392	107607
Ensembl	ENSG00000106100	ENSMUSG00000038058
UniProt	Q9Y239	Q8BHB0
RefSeq (mRNA)	NM_006092 NM_001354849	NM_001171007 NM_172729
RefSeq (protein)	NP_006083 NP_001341778	NP_001164478 NP_766317
Location (UCSC)	Chr 7: 30.42 – 30.48 Mb	Chr 6: 54.92 – 54.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

NOD1 protein contains a caspase recruitment domain (CARD). NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety, including bacterial peptidoglycan. Nod1 interacts with RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor NF-κB.

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.