Neutrophil cytosolic factor 2

 Neutrophil cytosol factor 2 is a protein that in humans is encoded by the NCF2 gene.

NCF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E96, 1HH8, 1K4U, 1OEY, 1WM5, 2DMO
Identifiers
Aliases	NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX, Neutrophil cytosolic factor 2
External IDs	OMIM: 608515 MGI: 97284 HomoloGene: 374 GeneCards: NCF2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 183,555,563 bp[1] End 183,590,876 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G3|1 65.05 cM Start 152,800,194 bp[2] End 152,836,991 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rac GTPase binding • superoxide-generating NADPH oxidase activity • protein C-terminus binding • GO:0001948 protein binding • electron transfer activity • superoxide-generating NADPH oxidase activator activity Cellular component • Acrosome • nucleolus • phagolysosome • cytoplasm • cytosol • NADPH oxidase complex Biological process • superoxide anion generation • cellular defense response • vascular endothelial growth factor receptor signaling pathway • innate immune system • oxidation-reduction process • superoxide metabolic process • phagocytosis • GO:0048554 positive regulation of catalytic activity • respiratory burst • electron transport chain • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • cellular response to oxidative stress • cell redox homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4688	17970
Ensembl	ENSG00000116701	ENSMUSG00000026480
UniProt	P19878	O70145
RefSeq (mRNA)	NM_000433 NM_001127651 NM_001190789 NM_001190794	NM_010877
RefSeq (protein)	NP_000424 NP_001121123 NP_001177718 NP_001177723	NP_035007
Location (UCSC)	Chr 1: 183.56 – 183.59 Mb	Chr 1: 152.8 – 152.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease.^[5]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.