Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the NCF1 gene.[5]
| NCF1 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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1GD5, 1K4U, 1KQ6, 1NG2, 1O7K, 1OV3, 1UEC, 1W70, 1WLP |
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| Identifiers |
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| Aliases | NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox, Neutrophil cytosolic factor 1 |
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| External IDs | OMIM: 608512 MGI: 97283 HomoloGene: 30964 GeneCards: NCF1 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 7 (human)[1] |
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| | Band | 7q11.23 | Start | 74,773,962 bp[1] |
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| End | 74,789,376 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 5 (mouse)[2] |
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| | Band | 5 G2|5 74.47 cM | Start | 134,220,053 bp[2] |
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| End | 134,229,625 bp[2] |
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| Gene ontology |
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| Molecular function | • superoxide-generating NADPH oxidase activity
• SH3 domain binding
• phosphatidylinositol-3,4-bisphosphate binding
• GO:0001948 protein binding
• phosphatidylinositol binding
• electron transfer activity
• lipid binding
• superoxide-generating NADPH oxidase activator activity
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| Cellular component | • cytoplasm
• cytosol
• membrane
• phagolysosome
• extrinsic component of membrane
• dendrite
• NADPH oxidase complex
• Golgi apparatus
• rough endoplasmic reticulum
• neuronal cell body
• podosomes
• cell membrane
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| Biological process | • protein targeting to membrane
• superoxide anion generation
• cellular defense response
• vascular endothelial growth factor receptor signaling pathway
• innate immune system
• superoxide metabolic process
• oxidation-reduction process
• apoptotic process
• respiratory burst
• podosome assembly
• positive regulation of phosphatidylinositol 3-kinase signaling
• cellular response to reactive oxygen species
• positive regulation of epidermal growth factor-activated receptor activity
• positive regulation of transcription, DNA-templated
• positive regulation of JNK cascade
• cellular response to cadmium ion
• positive regulation of p38MAPK cascade
• electron transport chain
• antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
• cellular response to oxidative stress
• cell redox homeostasis
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 7: 74.77 – 74.79 Mb | Chr 5: 134.22 – 134.23 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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FunctionEditThe protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.[5]
