NCDN

 Neurochondrin (also known as its murine homologue, Norbin) is a protein that in humans is encoded by the NCDN gene.^[5][6]

NCDN
Identifiers
Aliases	NCDN, neurochondrin
External IDs	OMIM: 608458 MGI: 1347351 HomoloGene: 8064 GeneCards: NCDN
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 35,557,473 bp[1] End 35,567,274 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 126,743,750 bp[2] End 126,753,438 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • neuron projection • axon • neuronal cell body • dendrite • cell projection • membrane • cell nucleus • cytosol Biological process • regulation of neuronal synaptic plasticity • neuron projection development • bone resorption Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23154	26562
Ensembl	ENSG00000020129	ENSMUSG00000028833
UniProt	Q9UBB6	Q9Z0E0
RefSeq (mRNA)	NM_014284 NM_001014839 NM_001014841	NM_011986 NM_001355412 NM_001355413
RefSeq (protein)	NP_001014839 NP_001014841 NP_055099	NP_036116 NP_001342341 NP_001342342
Location (UCSC)	Chr 1: 35.56 – 35.57 Mb	Chr 4: 126.74 – 126.75 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein norbin that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.^[6]

Norbin can modulate signaling activity and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition.^[7] Furthermore, norbin protein expression is altered in the schizophrenia brain.^[8]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.