NCAPG2

 Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene.^[5][6] CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis^[7]

NCAPG2
Identifiers
Aliases	NCAPG2, CAP-G2, CAPG2, LUZP5, MTB, hCAP-G2, non-SMC condensin II complex subunit G2, 3KS
External IDs	OMIM: 608532 MGI: 1923294 HomoloGene: 9820 GeneCards: NCAPG2
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.3 Start 158,631,169 bp[1] End 158,704,804 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F2 Start 116,405,402 bp[2] End 116,463,731 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methylated histone binding • GO:0001948 protein binding • bHLH transcription factor binding • molecular function regulator Cellular component • membrane • cell nucleus • nucleoplasm • condensin complex • nuclear speck Biological process • cell division • cell cycle • chromosome condensation • inner cell mass cell proliferation • transcription from RNA polymerase II promoter • erythrocyte differentiation • negative regulation of erythrocyte differentiation • positive regulation of protein tyrosine kinase activity • positive regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54892	76044
Ensembl	ENSG00000146918	ENSMUSG00000042029
UniProt	Q86XI2	Q6DFV1
RefSeq (mRNA)	NM_001281932 NM_001281933 NM_017760	NM_133762
RefSeq (protein)	NP_001268861 NP_001268862 NP_060230	NP_598523
Location (UCSC)	Chr 7: 158.63 – 158.7 Mb	Chr 12: 116.41 – 116.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical importanceEdit

Mutations in this gene in humans have been associated with severe neurodevelopmental defects, failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.^[8]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.