LRRTM1

 LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons.^[5][6] As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).^[7][8]

LRRTM1
Identifiers
Aliases	LRRTM1, entrez:347730, leucine rich repeat transmembrane neuronal 1
External IDs	OMIM: 610867 MGI: 2389173 HomoloGene: 41763 GeneCards: LRRTM1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p12 Start 80,288,351 bp[1] End 80,304,752 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 77,242,689 bp[2] End 77,257,791 bp[2]
Gene ontology Molecular function • protein kinase inhibitor activity • molecular function Cellular component • integral component of membrane • postsynaptic membrane • membrane • growth cone • cell membrane • synapse • excitatory synapse • cell surface • axon • cell junction • endoplasmic reticulum • extracellular • extracellular matrix • glutamatergic synapse • GABA-ergic synapse • integral component of postsynaptic membrane • integral component of postsynaptic specialization membrane Biological process • locomotory behavior • negative regulation of protein kinase activity • cytokine-mediated signaling pathway • negative regulation of receptor internalization • synapse organization • exploration behavior • protein localization to synapse • long-term synaptic potentiation • negative regulation of JAK-STAT cascade • positive regulation of synapse assembly • biological process • regulation of postsynaptic density assembly • regulation of presynapse assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	347730	74342
Ensembl	ENSG00000162951	ENSMUSG00000060780
UniProt	Q86UE6	Q8K377
RefSeq (mRNA)	NM_178839	NM_028880 NM_001362109
RefSeq (protein)	NP_849161	NP_083156 NP_001349038
Location (UCSC)	Chr 2: 80.29 – 80.3 Mb	Chr 6: 77.24 – 77.26 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical significanceEdit

LRRTM1 is the first gene linked to increased odds of being left-handed, when inherited from the father's side.^[9] Possessing one particular variant of the LRRTM1 gene slightly raises the risk of psychotic mental illnesses such as schizophrenia, again only if inherited from the father's side.^[9] As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations,^[10] indicating that the gene may have shared effects on neurodevelopment in both healthy and unhealthy individuals and individuals with schizophrenia.

LRRTM1 is also critically involved in synapse formation within the dorsal Lateral geniculate nucleus (dLGN) of mice. LRRTM1 aids in the assembly of complex retinogenciulate synapses in mice, which are believed to help process complex visual signals. Lack of this gene shows decreased performance in complex visual tasks.^[11]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.