Laminin subunit beta-3 is a protein that in humans is encoded by the LAMB3 gene.[5][6][7]
| LAMB3 |
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| Identifiers |
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| Aliases | LAMB3, BM600-125KDA, LAM5, LAMNB1, AI1A, Laminin, beta 3, laminin subunit beta 3 |
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| External IDs | OMIM: 150310 MGI: 99915 HomoloGene: 191 GeneCards: LAMB3 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1q32.2 | Start | 209,614,870 bp[1] |
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| End | 209,652,425 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 1 (mouse)[2] |
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| | Band | 1 H6|1 97.71 cM | Start | 193,207,699 bp[2] |
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| End | 193,343,878 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • GO:0001948 protein binding
• structural molecule activity
• GO:0032403 macromolecular complex binding
• extracellular matrix structural constituent
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| Cellular component | • extracellular region
• basement membrane
• laminin-5 complex
• collagen-containing extracellular matrix
• laminin complex
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| Biological process | • hemidesmosome assembly
• cell adhesion
• extracellular matrix organization
• endodermal cell differentiation
• brown fat cell differentiation
• epidermis development
• animal organ morphogenesis
• histogenesis
• cell migration
• substrate adhesion-dependent cell spreading
• basement membrane assembly
|
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_000228
NM_001017402
NM_001127641 |
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| RefSeq (protein) | |
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NP_000219
NP_001017402
NP_001121113 |
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| Location (UCSC) | Chr 1: 209.61 – 209.65 Mb | Chr 1: 193.21 – 193.34 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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LAMB3 encodes the beta 3 subunit of laminin. Laminin is composed of three subunits (alpha, beta, and gamma), and refers to a family of basement membrane proteins. For example, LAMB3 serves as the beta chain in laminin-5. Mutations in LAMB3 have been identified as the cause of various types of epidermolysis bullosa. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.[7]
