ITGA10

 Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.^[4][5][6]

ITGA10
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1PT6, 1QC5, 1QCY, 2L8S, 2M32, 4A0Q
Identifiers
Aliases	ITGA10, PRO827, integrin subunit alpha 10
External IDs	OMIM: 604042 MGI: 2153482 HomoloGene: 2697 GeneCards: ITGA10
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 145,891,208 bp[1] End 145,910,111 bp[1]
Gene ontology Molecular function • metal ion binding • collagen binding involved in cell-matrix adhesion • collagen binding Cellular component • integrin complex • cell membrane • membrane • integrin alpha10-beta1 complex • integral component of membrane Biological process • cell-matrix adhesion • extracellular matrix organization • cell adhesion • integrin-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8515	213119
Ensembl	ENSG00000143127	ENSMUSG00000090210
UniProt	O75578	n/a
RefSeq (mRNA)	NM_001303040 NM_001303041 NM_003637	NM_001081053 NM_001302471
RefSeq (protein)	NP_001289969 NP_001289970 NP_003628	n/a
Location (UCSC)	Chr 1: 145.89 – 145.91 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.^[4]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.