IRAK2

 Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.^[5][6]

IRAK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MOP
Identifiers
Aliases	IRAK2, IRAK-2, interleukin 1 receptor associated kinase 2
External IDs	OMIM: 603304 MGI: 2429603 HomoloGene: 1207 GeneCards: IRAK2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 10,164,919 bp[1] End 10,243,745 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 E3|6 52.82 cM Start 113,638,467 bp[2] End 113,695,026 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • protein kinase activity • protein homodimerization activity • protein serine/threonine kinase activity • GO:0001948 protein binding • protein heterodimerization activity • ATP binding Cellular component • cytoplasm • cytosol • cell membrane • endosome membrane • cell nucleus Biological process • response to interleukin-1 • negative regulation of sequence-specific DNA binding transcription factor activity • toll-like receptor signaling pathway • protein phosphorylation • JNK cascade • activation of MAPK activity • positive regulation of NF-kappaB transcription factor activity • toll-like receptor 9 signaling pathway • negative regulation of NF-kappaB transcription factor activity • nucleotide-binding oligomerization domain containing signaling pathway • lipopolysaccharide-mediated signaling pathway • signal transduction • regulation of cytokine-mediated signaling pathway • I-kappaB kinase/NF-kappaB signaling • inflammatory response • MyD88-dependent toll-like receptor signaling pathway • GO:0007243 intracellular signal transduction • interleukin-1-mediated signaling pathway • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3656	108960
Ensembl	ENSG00000134070	ENSMUSG00000060477
UniProt	O43187	Q8CFA1
RefSeq (mRNA)	NM_001570	NM_001113553 NM_172161
RefSeq (protein)	NP_001561	NP_001107025 NP_751893
Location (UCSC)	Chr 3: 10.16 – 10.24 Mb	Chr 6: 113.64 – 113.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.^[6]

InteractionsEdit

IRAK2 has been shown to interact with TRAF6^[5][7] and Myd88.^[5][7][8]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.