GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine.[5] GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle,[6] testis, kidney, fat tissue (adipocytes), and brain.[7]
| SLC2A5 |
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| Identifiers |
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| Aliases | SLC2A5, GLUT-5, GLUT5, solute carrier family 2 member 5 |
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| External IDs | OMIM: 138230 MGI: 1928369 HomoloGene: 74459 GeneCards: SLC2A5 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1p36.23 | Start | 9,035,106 bp[1] |
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| End | 9,088,478 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 4 (mouse)[2] |
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| | Band | 4|4 E2 | Start | 150,119,283 bp[2] |
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| End | 150,144,169 bp[2] |
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| Gene ontology |
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| Molecular function | • GO:0022891 transmembrane transporter activity
• transporter activity
• fructose binding
• fructose transmembrane transporter activity
• glucose transmembrane transporter activity
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| Cellular component | • integral component of membrane
• membrane
• cell membrane
• integral component of plasma membrane
• apical plasma membrane
• sarcolemma
• extracellular exosome
• specific granule membrane
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| Biological process | • cellular response to fructose stimulus
• fructose transport
• carbohydrate transport
• fructose import across plasma membrane
• response to fructose
• transmembrane transport
• glucose transmembrane transport
• regulation of systemic arterial blood pressure mediated by a chemical signal
• neutrophil degranulation
• intestinal hexose absorption
• transport
• carbohydrate metabolic process
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001135585
NM_003039
NM_001328619
NM_001328620
NM_001328621 |
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| RefSeq (protein) | |
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NP_001129057
NP_001315548
NP_001315549
NP_001315550
NP_003030 |
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| Location (UCSC) | Chr 1: 9.04 – 9.09 Mb | Chr 4: 150.12 – 150.14 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.[8]
In humans the GLUT5 protein is encoded by the SLC2A5 gene.[9]
RegulationEditFructose uptake rate by GLUT5 is significantly affected by diabetes mellitus, hypertension, obesity, fructose malabsorption, and inflammation. However, age-related changes in fructose intake capability are not explained by the rate of expression of GLUT5.[10][11][12] The absorption of fructose in the simultaneous presence of glucose is improved, while sorbitol is inhibitory.[13] Fructose absorption by GLUT5 can be investigated using intestinal organoids.[14][15]
