Gamma-aminobutyric acid (GABA) B receptor, 1 (GABAB1), is a G-protein coupled receptor subunit encoded by the GABBR1 gene.
| GABBR1 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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4MQE, 4MQF, 4MR7, 4MR9, 4MRM, 4MS1, 4MS3, 4MS4, 4PAS |
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| Identifiers |
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| Aliases | GABBR1, GABABR1, GABBR1-3, GB1, GPRC3A, dJ271M21.1.1, dJ271M21.1.2, gamma-aminobutyric acid type B receptor subunit 1 |
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| External IDs | OMIM: 603540 MGI: 1860139 HomoloGene: 1132 GeneCards: GABBR1 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 6 (human)[1] |
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| | Band | 6p22.1 | Start | 29,555,629 bp[1] |
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| End | 29,633,976 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 17 (mouse)[2] |
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| | Band | 17 B1|17 19.16 cM | Start | 37,045,966 bp[2] |
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| End | 37,075,067 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • G-protein coupled receptor activity
• signal transducer activity
• GO:0001948 protein binding
• G-protein coupled GABA receptor activity
• G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
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| Cellular component | • cytoplasm
• integral component of membrane
• G-protein coupled receptor dimeric complex
• postsynaptic membrane
• cell projection
• membrane
• cell membrane
• synapse
• integral component of plasma membrane
• extracellular region
• cell junction
• dendrite
• G-protein coupled receptor heterodimeric complex
• presynaptic membrane
• presynapse
• Schaffer collateral - CA1 synapse
• GABA-ergic synapse
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| Biological process | • gamma-aminobutyric acid signaling pathway
• adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
• signal transduction
• negative regulation of adenylate cyclase activity
• G-protein coupled receptor signaling pathway
• postsynaptic potential
• neuron-glial cell signaling
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | ENSG00000237112
ENSG00000206511
ENSG00000206466
ENSG00000232632
ENSG00000232569
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ENSG00000237051
ENSG00000204681 |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001470
NM_021903
NM_021904
NM_021905
NM_001319053 |
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| RefSeq (protein) | |
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NP_001305982
NP_001461
NP_068703
NP_068704 |
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| Location (UCSC) | Chr 6: 29.56 – 29.63 Mb | Chr 17: 37.05 – 37.08 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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FunctionEditGamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.[5]
InteractionsEditGABBR1 has been shown to interact with ATF4[6] and GABBR2.[7]
