FABP7

 Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.^[5]

FABP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FDQ, 1FE3, 1JJX
Identifiers
Aliases	FABP7, B-FABP, BLBP, FABPB, MRG, LTR2-fatty acid binding protein 7
External IDs	OMIM: 602965 MGI: 101916 HomoloGene: 37880 GeneCards: FABP7
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q22.31 Start 122,779,716 bp[1] End 122,784,074 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 57,784,881 bp[2] End 57,788,450 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • lipid binding Cellular component • cell body • neuronal cell body • cell projection • cell periphery • cell nucleus • intercellular junction • cytoplasm • cytosol Biological process • negative regulation of cell proliferation • triglyceride catabolic process • neurogenesis • epithelial cell proliferation • cell proliferation in forebrain • startle response • nervous system development • prepulse inhibition Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2173	12140
Ensembl	ENSG00000164434	ENSMUSG00000019874
UniProt	O15540	P51880
RefSeq (mRNA)	NM_001446 NM_001319039 NM_001319041 NM_001319042	NM_021272
RefSeq (protein)	NP_001305968 NP_001305970 NP_001305971 NP_001437	NP_067247
Location (UCSC)	Chr 6: 122.78 – 122.78 Mb	Chr 10: 57.78 – 57.79 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.^[5]

FABP7 is expressed, during development, in radial glia by the activation of Notch receptors.^[6] Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation.^[7]

According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.^[8]

Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.

Role in pathologyEdit

FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.^[9]

As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,^[10] with one, that tested for only one SNP, showing negative^[11] and another, with seven SNPs,^[12] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.