CRMP1

 Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.^[5]

CRMP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B3Z
Identifiers
Aliases	CRMP1, CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3, collapsin response mediator protein 1
External IDs	OMIM: 602462 MGI: 107793 HomoloGene: 20347 GeneCards: CRMP1
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.2 Start 5,748,084 bp[1] End 5,893,086 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B3|5 19.96 cM Start 37,241,940 bp[2] End 37,292,133 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • hydrolase activity • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds • filamin binding Cellular component • spindle • cytoskeleton • microtubule organizing center • cytoplasm • cytosol • midbody • centrosome • cell nucleus Biological process • neuron development • nucleobase-containing compound metabolic process • microtubule cytoskeleton organization • nervous system development • axon guidance • negative regulation of actin filament binding • negative regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1400	12933
Ensembl	ENSG00000072832	ENSMUSG00000029121
UniProt	Q14194	P97427
RefSeq (mRNA)	NM_001313 NM_001014809 NM_001288661 NM_001288662	NM_001136058 NM_007765
RefSeq (protein)	NP_001014809 NP_001275590 NP_001275591 NP_001304	NP_001129530 NP_031791
Location (UCSC)	Chr 4: 5.75 – 5.89 Mb	Chr 5: 37.24 – 37.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.^[5]

CRMP1 mediates reelin signaling in cortical neuronal migration.^[6] Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory.^[7]

CRMP1 gene overlaps with another gene called EVC.^[8]

InteractionsEdit

CRMP1 has been shown to interact with DPYSL2.^[9]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.