CLCN3

 H⁺/Cl⁻ exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene.^[5]

CLCN3
Identifiers
Aliases	CLCN3, CLC3, ClC-3, chloride voltage-gated channel 3
External IDs	OMIM: 600580 MGI: 103555 HomoloGene: 20435 GeneCards: CLCN3
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q33 Start 169,612,633 bp[1] End 169,723,673 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.1|8 30.9 cM Start 60,910,389 bp[2] End 60,983,300 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • volume-sensitive chloride channel activity • PDZ domain binding • protein homodimerization activity • ion channel activity • GO:0001948 protein binding • protein heterodimerization activity • antiporter activity • ATP binding • chloride channel activity • voltage-gated chloride channel activity • solute:proton antiporter activity • chloride ion binding Cellular component • integral component of membrane • endosome • late endosome • Golgi apparatus • early endosome membrane • membrane • late endosome membrane • synaptic vesicle • vesicle membrane • Golgi membrane • cell membrane • transport vesicle membrane • secretory granule • cell surface • early endosome • specific granule • phagocytic vesicle • external side of plasma membrane • cytoplasmic vesicle • integral component of plasma membrane Biological process • negative regulation of cell volume • endosomal lumen acidification • ion transport • regulation of anion transmembrane transport • chloride transport • regulation of pH • chloride transmembrane transport • regulation of anion transport • transmembrane transport • transport • synaptic vesicle lumen acidification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1182	12725
Ensembl	ENSG00000109572	ENSMUSG00000004319
UniProt	P51790	P51791
RefSeq (mRNA)	NM_001243372 NM_001243374 NM_001829 NM_173872	NM_007711 NM_173873 NM_173874 NM_173876
RefSeq (protein)	NP_001230301 NP_001230303 NP_001820 NP_776297	NP_031737 NP_776298 NP_776299 NP_776301
Location (UCSC)	Chr 4: 169.61 – 169.72 Mb	Chr 8: 60.91 – 60.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

InteractionsEdit

CLCN3 has been shown to interact with PDZK1.^[6]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.