CDK5R2

 Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.^[5][6]

CDK5R2
Identifiers
Aliases	CDK5R2, NCK5AI, P39, p39nck5ai, cyclin-dependent kinase 5, regulatory subunit 2 (p39), cyclin dependent kinase 5 regulatory subunit 2
External IDs	OMIM: 603764 MGI: 1330828 HomoloGene: 2924 GeneCards: CDK5R2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 218,959,666 bp[1] End 218,962,155 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 74,854,934 bp[2] End 74,857,732 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0016534 cyclin-dependent protein serine/threonine kinase activator activity • lipid binding • actin binding Cellular component • cytoplasm • cyclin-dependent protein kinase 5 holoenzyme complex • cell membrane • membrane • growth cone • neuron projection Biological process • positive regulation of protein kinase activity • regulation of cyclin-dependent protein serine/threonine kinase activity • neuron migration • hippocampus development • layer formation in cerebral cortex • cerebellum development • positive regulation of protein serine/threonine kinase activity • superior olivary nucleus maturation • positive regulation of calcium ion-dependent exocytosis • positive regulation of cyclin-dependent protein serine/threonine kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8941	12570
Ensembl	ENSG00000171450	ENSMUSG00000090071
UniProt	Q13319	O35926
RefSeq (mRNA)	NM_003936	NM_009872
RefSeq (protein)	NP_003927	NP_034002
Location (UCSC)	Chr 2: 218.96 – 218.96 Mb	Chr 1: 74.85 – 74.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase-activating proteins.^[6]

InteractionsEdit

CDK5R2 has been shown to interact with Actinin, alpha 1.^[7]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.