CD2

 CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2,^[5] LFA-3 receptor, erythrocyte receptor and rosette receptor.^[6]

CD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CDB, 1GYA, 1HNF, 1L2Z, 1QA9, 2J6O, 2J7I
Identifiers
Aliases	CD2, LFA-2, SRBC, T11, CD2 molecule
External IDs	OMIM: 186990 MGI: 88320 HomoloGene: 1338 GeneCards: CD2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.1 Start 116,754,430 bp[1] End 116,769,229 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 44.17 cM Start 101,275,899 bp[2] End 101,287,939 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • GO:0001948 protein binding • receptor binding • signaling receptor activity • antigen binding • protein kinase binding • receptor tyrosine kinase binding • protein self-association Cellular component • integral component of membrane • membrane • intercellular junction • anchored component of plasma membrane • integral component of plasma membrane • extracellular region • cell surface • cytoplasmic side of plasma membrane • external side of plasma membrane • cell membrane • macromolecular complex • membrane raft Biological process • positive regulation of myeloid dendritic cell activation • heterotypic cell-cell adhesion • natural killer cell activation • membrane raft polarization • cell surface receptor signaling pathway • cell adhesion • positive regulation of tumor necrosis factor production • T cell activation • leukocyte migration • regulation of T cell differentiation • apoptotic process • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	914	12481
Ensembl	ENSG00000116824	ENSMUSG00000027863
UniProt	P06729 Q53F96	P08920
RefSeq (mRNA)	NM_001767 NM_001328609	NM_013486
RefSeq (protein)	NP_001315538 NP_001758 NP_001758.2	NP_038514
Location (UCSC)	Chr 1: 116.75 – 116.77 Mb	Chr 3: 101.28 – 101.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.^[7]

In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells.^[8]

Diagnostic relevanceEdit

CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms.^[9]

ClassificationEdit

Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion.^[8]

InteractionsEdit

CD2 has been shown to interact with CD2BP2,^[10] Lck^[11] and PSTPIP1.^[12]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.