CD120

 CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).[1][2]

tumor necrosis factor receptor superfamily, member 1A
Identifiers
SymbolTNFRSF1A
Alt. symbolsCD120a, TNFR1
NCBI gene7132
HGNC11916
OMIM191190
RefSeqNM_001065
UniProtP19438
Other data
LocusChr. 12 p13.2
tumor necrosis factor receptor superfamily, member 1B
Identifiers
SymbolTNFRSF1B
Alt. symbolsCD120a, TNFR2
NCBI gene7133
HGNC11917
OMIM191191
RefSeqNM_001066
UniProtP20333
Other data
LocusChr. 1 p36.22

Receptor subtypesEdit

There are two variants of the receptor, each encoded by a separate gene:

  • CD120a - TNFR1 - TNFR superfamily member 1A
  • CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]

Signaling pathwayEdit

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

This article uses material from the Wikipedia article
 Metasyntactic variable, which is released under the 
Creative Commons
Attribution-ShareAlike 3.0 Unported License.