BCL6

 B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene.^[5] Like BCL2, BCL3, BCL5, BCL7A, BCL9 and BCL10, it has clinical significance in lymphoma.

BCL6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R28, 1R29, 1R2B, 2EN2, 2EOS, 2LCE, 2YRM, 3BIM, 3E4U, 3LBZ, 4CP3, 4U2M
Identifiers
Aliases	BCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51, B-cell CLL/lymphoma 6, B cell CLL/lymphoma 6, transcription repressor, BCL6 transcription repressor
External IDs	OMIM: 109565 MGI: 107187 HomoloGene: 7640 GeneCards: BCL6
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.3 Start 187,721,377 bp[1] End 187,745,725 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 B1|16 15.26 cM Start 23,965,052 bp[2] End 23,988,852 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • intronic transcription regulatory region sequence-specific DNA binding • chromatin binding • metal ion binding • GO:0001948 protein binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • nucleic acid binding • chromatin DNA binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • replication fork • cell nucleus • nucleoplasm • Golgi apparatus Biological process • regulation of germinal center formation • positive regulation of histone deacetylation • negative regulation of T-helper 2 cell differentiation • protein localization • negative regulation of mast cell cytokine production • regulation of transcription, DNA-templated • immune system process • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • regulation of transcription from RNA polymerase II promoter • negative regulation of cell differentiation • germinal center formation • negative regulation of Rho protein signal transduction • negative regulation of isotype switching to IgE isotypes • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • type 2 immune response • cellular response to DNA damage stimulus • negative regulation of cell-matrix adhesion • regulation of cell proliferation • positive regulation of B cell proliferation • negative regulation of cell growth • Rho protein signal transduction • cell morphogenesis • spermatogenesis • regulation of memory T cell differentiation • positive regulation of neuron differentiation • regulation of inflammatory response • regulation of immune response • positive regulation of apoptotic process • negative regulation of type 2 immune response • negative regulation of B cell apoptotic process • positive regulation of cellular component movement • B cell differentiation • inflammatory response • negative regulation of transcription, DNA-templated • actin cytoskeleton organization • negative regulation of cell proliferation • negative regulation of Notch signaling pathway • erythrocyte development • negative regulation of cellular senescence • regulation of apoptotic process • negative regulation of mitotic cell cycle DNA replication • positive regulation of regulatory T cell differentiation • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	604	12053
Ensembl	ENSG00000113916	ENSMUSG00000022508
UniProt	P41182	P41183
RefSeq (mRNA)	NM_001130845 NM_001134738 NM_001706 NM_138931	NM_009744 NM_001348026
RefSeq (protein)	NP_001124317 NP_001128210 NP_001697	NP_001334955 NP_033874
Location (UCSC)	Chr 3: 187.72 – 187.75 Mb	Chr 16: 23.97 – 23.99 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

The protein encoded by this gene is an evolutionarily conserved zinc finger transcription factor and contains an N-terminal POZ/BTB domain. This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the STAT-dependent Interleukin 4 (IL-4) responses of B cells. This protein can interact with several corepressor complexes to inhibit transcription. This gene is found to be frequently translocated and hypermutated in diffuse large B cell lymphoma (DLBCL)^[6][7][8] and contributes to the pathogenesis of DLBCL. An exon 7 skipping splice variant encodes a shorter form of the protein which lacks the first two zinc fingers of the DNA binding domain.^[9]

Physiologically, BCL6 is a master transcription factor which leads the differentiation of naive helper T cells in Follicular Helper T cells (TFH cells).^[10] Its action is negatively regulated by the gene PRDM1 encoding the transcription factor Blimp-1.^[11]

Diagnostic utilityEdit

The presence of BCL6 can be demonstrated in tissue sections using immunohistochemistry. It is exclusively present in the B-cells of both healthy and neoplastic germinal centres. It therefore demonstrates both reactive hyperplasia in lymph nodes and a range of lymphomas derived from follicular B-cells, such as Burkitt's lymphoma, follicular lymphoma and the nodular lymphocyte predominant subtype of Hodgkin's disease. It is often used together with antibodies to Bcl-2 antigen to distinguish neoplastic follicles from those found in benign hyperplasia, for which Bcl-2 is negative.^[12]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.