Apolipoprotein M is a protein that in humans is encoded by the APOM gene.[5][6][7]
| APOM |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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2WEW, 2WEX, 2YG2 |
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| Identifiers |
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| Aliases | APOM, G3a, HSPC336, NG20, apo-M, apolipoprotein M |
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| External IDs | OMIM: 606907 MGI: 1930124 HomoloGene: 10308 GeneCards: APOM |
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| Gene location (Human) |
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 | | Chr. | Chromosome 6 (human)[1] |
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| | Band | 6p21.33 | Start | 31,652,416 bp[1] |
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| End | 31,658,210 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 17 (mouse)[2] |
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| | Band | 17|17 B1 | Start | 35,128,997 bp[2] |
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| End | 35,132,050 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • lipid transporter activity
• antioxidant activity
• phospholipid binding
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| Cellular component | • discoidal high-density lipoprotein particle
• integral component of plasma membrane
• very-low-density lipoprotein particle
• spherical high-density lipoprotein particle
• extracellular region
• low-density lipoprotein particle
• high-density lipoprotein particle
• extracellular
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| Biological process | • lipoprotein metabolic process
• lipid transport
• negative regulation of plasma lipoprotein oxidation
• response to glucose
• high-density lipoprotein particle assembly
• retinoid metabolic process
• high-density lipoprotein particle remodeling
• cholesterol efflux
• cholesterol homeostasis
• reverse cholesterol transport
• high-density lipoprotein particle clearance
• cellular oxidant detoxification
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | ENSG00000231974
ENSG00000204444
ENSG00000206409
ENSG00000227567
ENSG00000235754
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ENSG00000224290
ENSG00000226215 |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 6: 31.65 – 31.66 Mb | Chr 17: 35.13 – 35.13 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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| ApoM |
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| Identifiers |
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| Symbol | ApoM |
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| Pfam | PF11032 |
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| Pfam clan | CL0116 |
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| InterPro | IPR022734 |
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| Available protein structures: |
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| Pfam | structures / ECOD |
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| PDB | RCSB PDB; PDBe; PDBj |
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| PDBsum | structure summary |
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The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized.[7] The average molecular weight is 21253 Da, and the monoisotopic molecular weight is 21239 Da.
