APOA2

 Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.^[5]

APOA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1L6L, 2OU1
Identifiers
Aliases	APOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2
External IDs	MGI: 88050 HomoloGene: 1242 GeneCards: APOA2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,222,292 bp[1] End 161,223,631 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 79.22 cM Start 171,225,054 bp[2] End 171,226,379 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • lipase inhibitor activity • protein homodimerization activity • phosphatidylcholine binding • lipid transporter activity • apolipoprotein receptor binding • high-density lipoprotein particle receptor binding • cholesterol binding • GO:0001948 protein binding • protein heterodimerization activity • phosphatidylcholine-sterol O-acyltransferase activator activity • phospholipid binding • GO:0017127 cholesterol transfer activity • lipid binding • high-density lipoprotein particle binding • heat shock protein binding • receptor binding Cellular component • cytosol • blood microparticle • endoplasmic reticulum lumen • chylomicron • very-low-density lipoprotein particle • spherical high-density lipoprotein particle • extracellular region • early endosome • high-density lipoprotein particle • extracellular exosome • extracellular Biological process • negative regulation of cholesterol import • negative regulation of very-low-density lipoprotein particle remodeling • diacylglycerol catabolic process • lipid transport • regulation of protein stability • positive regulation of cholesterol esterification • phospholipid efflux • cholesterol transport • positive regulation of lipid catabolic process • response to glucocorticoid • GO:0002719 negative regulation of cytokine production involved in immune response • response to glucose • high-density lipoprotein particle assembly • retinoid metabolic process • response to estrogen • high-density lipoprotein particle remodeling • negative regulation of lipase activity • regulation of intestinal cholesterol absorption • low-density lipoprotein particle remodeling • acute inflammatory response • animal organ regeneration • phospholipid catabolic process • peptidyl-methionine modification • cholesterol efflux • negative regulation of cholesterol transport • cholesterol homeostasis • phosphatidylcholine biosynthetic process • negative regulation of cholesterol transporter activity • GO:0022415 viral process • negative regulation of lipid catabolic process • protein oxidation • triglyceride-rich lipoprotein particle remodeling • response to drug • triglyceride metabolic process • reverse cholesterol transport • high-density lipoprotein particle clearance • GO:0048554 positive regulation of catalytic activity • cholesterol metabolic process • regulation of lipid metabolic process • chylomicron remodeling • chylomicron assembly • lipoprotein metabolic process • post-translational modification • cellular protein metabolic process • transport • positive regulation of phagocytosis • protein stabilization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	336	11807
Ensembl	ENSG00000158874	ENSMUSG00000005681
UniProt	P02652	P09813
RefSeq (mRNA)	NM_001643	NM_013474 NM_001305549 NM_001305550 NM_001305585
RefSeq (protein)	NP_001634	NP_001292478 NP_001292479 NP_001292514 NP_038502
Location (UCSC)	Chr 1: 161.22 – 161.22 Mb	Chr 1: 171.23 – 171.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ApoA-II
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
Symbol	ApoA-II
Pfam	PF04711
InterPro	IPR006801
SCOP2	1l6k / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

FunctionEdit

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.^[6]

InteractionsEdit

APOA2 has been shown to interact with PLTP.^[7]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.