Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1 gene.
| ACP1 |
|---|
 |
| Available structures |
|---|
| PDB | Ortholog search: PDBe RCSB |
|---|
| List of PDB id codes |
|---|
1XWW, 3N8I, 4Z99, 4Z9A, 4Z9B, 5PNT |
|
|
| Identifiers |
|---|
| Aliases | ACP1, HAAP, LMW-PTP, acid phosphatase 1, soluble, LMWPTP, acid phosphatase 1 |
|---|
| External IDs | OMIM: 171500 MGI: 87881 HomoloGene: 38274 GeneCards: ACP1 |
|---|
| EC number | 3.1.3.2 |
|---|
| Gene location (Human) |
|---|
 | | Chr. | Chromosome 2 (human)[1] |
|---|
| | Band | 2p25.3 | Start | 264,140 bp[1] |
|---|
| End | 278,283 bp[1] |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 12 (mouse)[2] |
|---|
| | Band | 12|12 A2 | Start | 30,893,326 bp[2] |
|---|
| End | 30,911,589 bp[2] |
|---|
|
| RNA expression pattern |
|---|
 | | More reference expression data |
|
| Gene ontology |
|---|
| Molecular function | • protein tyrosine phosphatase activity
• phosphatase activity
• phosphoprotein phosphatase activity
• hydrolase activity
• GO:0001948 protein binding
• non-membrane spanning protein tyrosine phosphatase activity
• acid phosphatase activity
|
|---|
| Cellular component | • cytoplasm
• cytoplasmic side of plasma membrane
• extracellular exosome
• cytosol
• sarcolemma
|
|---|
| Biological process | • protein dephosphorylation
• peptidyl-tyrosine dephosphorylation
|
|---|
| Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | |
|---|
NM_001040649
NM_004300
NM_007099
NM_177554 |
| |
|---|
| RefSeq (protein) | |
|---|
NP_001035739
NP_004291
NP_009030 |
| |
|---|
| Location (UCSC) | Chr 2: 0.26 – 0.28 Mb | Chr 12: 30.89 – 30.91 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.[5]
InteractionsEditACP1 has been shown to interact with EPH receptor A2[6] and EPH receptor B1.[7]
