TSPAN4

 Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.^[5][6]

TSPAN4
Identifiers
Aliases	TSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDs	OMIM: 602644 MGI: 1928097 HomoloGene: 2453 GeneCards: TSPAN4
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 842,812 bp[1] End 867,116 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 141,475,240 bp[2] End 141,493,427 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • antigen binding • integrin binding • GO:0001948 protein binding Cellular component • integral component of membrane • vesicle • cell membrane • integral component of plasma membrane • membrane • focal adhesion Biological process • cell surface receptor signaling pathway • macromolecular complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7106	64540
Ensembl	ENSG00000214063	ENSMUSG00000025511
UniProt	O14817	Q9DCK3
RefSeq (mRNA)	NM_001025234 NM_001025235 NM_001025236 NM_001025237 NM_001025238 NM_001025239 NM_003271	NM_001252588 NM_053082
RefSeq (protein)	NP_001020405 NP_001020406 NP_001020407 NP_001020408 NP_001020409 NP_001020410 NP_003262	NP_001239517 NP_444312
Location (UCSC)	Chr 11: 0.84 – 0.87 Mb	Chr 7: 141.48 – 141.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

InteractionsEdit

TSPAN4 has been shown to interact with CD9,^[5] ITGA6,^[5] CD29,^[5] CD49c^[5] and CD81.^[5]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.