Spondin 1

 Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.^[5] It is secreted by cells of the floor plate and may be involved in axon guidance^[6] The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

SPON1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZOT, 2ZOU, 3COO, 3Q13
Identifiers
Aliases	SPON1, VSGP/F-spondin, f-spondin, Spondin 1
External IDs	OMIM: 604989 MGI: 2385287 HomoloGene: 4453 GeneCards: SPON1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.2 Start 13,962,723 bp[1] End 14,268,133 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 113,765,998 bp[2] End 114,043,370 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • extracellular matrix structural constituent • LBD domain binding Cellular component • extracellular matrix • extracellular region • endoplasmic reticulum lumen • extracellular • collagen-containing extracellular matrix Biological process • cell adhesion • protein O-linked fucosylation • positive regulation of protein processing • positive regulation of protein binding • negative regulation of amyloid-beta formation • positive regulation of amyloid precursor protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10418	233744
Ensembl	ENSG00000262655	ENSMUSG00000038156
UniProt	Q9HCB6	Q8VCC9
RefSeq (mRNA)	NM_006108	NM_145584
RefSeq (protein)	NP_006099	NP_663559
Location (UCSC)	Chr 11: 13.96 – 14.27 Mb	Chr 7: 113.77 – 114.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.