SMC2

 Structural maintenance of chromosomes protein 2 (SMC-2) also known as chromosome-associated protein E (CAP-E) is a protein that in humans is encoded by the SMC2 gene.^[5][6]

SMC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4U4P
Identifiers
Aliases	SMC2, CAP-E, CAPE, SMC-2, SMC2L1, structural maintenance of chromosomes 2
External IDs	OMIM: 605576 MGI: 106067 HomoloGene: 4705 GeneCards: SMC2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.1 Start 104,094,260 bp[1] End 104,141,419 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 B2|4 28.31 cM Start 52,439,243 bp[2] End 52,488,260 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GO:0001948 protein binding • protein heterodimerization activity • ATP binding • single-stranded DNA binding Cellular component • cytoplasm • cytosol • chromosome • nucleoplasm • condensin complex • nuclear chromosome • nucleolus • extracellular exosome • condensed chromosome • cell nucleus Biological process • kinetochore organization • meiotic chromosome condensation • chromosome organization • meiotic chromosome segregation • cell division • chromosome condensation • cell cycle • mitotic chromosome condensation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10592	14211
Ensembl	ENSG00000136824	ENSMUSG00000028312
UniProt	O95347 Q05D74	Q8CG48
RefSeq (mRNA)	NM_001042550 NM_001042551 NM_001265602 NM_006444	NM_001301412 NM_008017
RefSeq (protein)	NP_001036015 NP_001036016 NP_001252531 NP_006435 NP_006435.2	NP_001288341 NP_032043
Location (UCSC)	Chr 9: 104.09 – 104.14 Mb	Chr 4: 52.44 – 52.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

SMC-2 is a subunit of condensin I and II, large protein complexes involved in chromosome condensation.

InteractionsEdit

SMC2 has been shown to interact with DNMT3B.^[7]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.