RAC2

 Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.^[5] It is encoded by the gene RAC2.^[6]

RAC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DS6, 2W2T, 2W2V, 2W2X
Identifiers
Aliases	RAC2, EN-7, Gx, HSPC022, p21-Rac2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), Rac family small GTPase 2
External IDs	OMIM: 602049 MGI: 97846 HomoloGene: 55699 GeneCards: RAC2
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,225,270 bp[1] End 37,244,448 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 78,559,167 bp[2] End 78,572,783 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • protein kinase regulator activity • GTPase activity • GO:0001948 protein binding Cellular component • cytoplasm • cytosol • phagocytic vesicle membrane • nuclear envelope • membrane • focal adhesion • cell membrane • actin filament • extracellular exosome • lamellipodium • intracellular Biological process • regulation of respiratory burst • lymphocyte aggregation • regulation of T cell proliferation • positive regulation of protein targeting to mitochondrion • regulation of hydrogen peroxide metabolic process • actin filament organization • regulation of cell-substrate adhesion • regulation of neutrophil migration • bone resorption • platelet activation • chemotaxis • cell projection assembly • positive regulation of cell proliferation • regulation of mast cell chemotaxis • positive regulation of neutrophil chemotaxis • regulation of mast cell degranulation • regulation of protein kinase activity • positive regulation of lamellipodium assembly • regulation of small GTPase mediated signal transduction • actin cytoskeleton organization • signal transduction • small GTPase mediated signal transduction • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5880	19354
Ensembl	ENSG00000128340	ENSMUSG00000033220
UniProt	P15153	Q05144
RefSeq (mRNA)	NM_002872	NM_009008
RefSeq (protein)	NP_002863	NP_033034
Location (UCSC)	Chr 22: 37.23 – 37.24 Mb	Chr 15: 78.56 – 78.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.^[6]

InteractionsEdit

Rac2 has been shown to interact with ARHGDIA^[7][8] and Nitric oxide synthase 2A.^[9]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.