Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.[5]
| OGN |
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| Identifiers |
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| Aliases | OGN, OG, OIF, SLRR3A, osteoglycin |
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| External IDs | OMIM: 602383 MGI: 109278 HomoloGene: 8542 GeneCards: OGN |
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| Gene location (Human) |
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 | | Chr. | Chromosome 9 (human)[1] |
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| | Band | 9q22.31 | Start | 92,383,268 bp[1] |
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| End | 92,404,696 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 13 (mouse)[2] |
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| | Band | 13|13 A5 | Start | 49,608,046 bp[2] |
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| End | 49,624,501 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • GO:0001948 protein binding
• growth factor activity
• extracellular matrix structural constituent conferring compression resistance
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| Cellular component | • extracellular vesicle
• extracellular matrix
• lysosomal lumen
• Golgi lumen
• extracellular exosome
• extracellular
• extracellular region
• collagen-containing extracellular matrix
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| Biological process | • negative regulation of smooth muscle cell proliferation
• axonogenesis
• keratan sulfate catabolic process
• keratan sulfate biosynthetic process
• regulation of receptor activity
• signal transduction
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_033014
NM_014057
NM_024416 |
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| RefSeq (protein) | |
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NP_054776
NP_077727
NP_148935
NP_054776.1
NP_148935.1 |
| |
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| Location (UCSC) | Chr 9: 92.38 – 92.4 Mb | Chr 13: 49.61 – 49.62 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small keratan sulfate proteoglycan[6] which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.[5]
The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.[7][8]
