NLRX1 or NLR family member X1, short for nucleotide-binding oligomerization domain, leucine rich repeat containing X1 is a protein that in humans is encoded by the NLRX1 gene.[5][6] It is also known as NOD-like receptor X1, NLR family, X1, NOD5, NOD9, and CLR11.3, and is a member of the NOD-like receptor family of pattern recognition receptors.
| NLRX1 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | NLRX1, CLR11.3, DLNB26, NOD26, NOD5, NOD9, NLR family member X1 |
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| External IDs | OMIM: 611947 MGI: 2429611 HomoloGene: 11623 GeneCards: NLRX1 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 11 (human)[1] |
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| | Band | 11q23.3 | Start | 119,166,568 bp[1] |
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| End | 119,184,016 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 9 (mouse)[2] |
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| | Band | 9|9 A5.2 | Start | 44,252,717 bp[2] |
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| End | 44,268,599 bp[2] |
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| Gene ontology |
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| Molecular function | • nucleotide binding
• GO:0001948 protein binding
• ATP binding
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| Cellular component | • mitochondrial outer membrane
• membrane
• mitochondrion
• cell membrane
• cell junction
• cytoplasm
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| Biological process | • negative regulation of interleukin-6 production
• negative regulation of type I interferon production
• GO:0022415 viral process
• negative regulation of inflammatory response
• negative regulation of interferon-beta production
• negative regulation of RIG-I signaling pathway
• negative regulation of I-kappaB kinase/NF-kappaB signaling
• immune system process
• negative regulation of innate immune response
• innate immune system
• GO:0007243 intracellular signal transduction
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001282143
NM_001282144
NM_001282358
NM_024618
NM_170722 |
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NM_001163742
NM_001163743
NM_178420 |
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| RefSeq (protein) | |
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NP_001269072
NP_001269073
NP_001269287
NP_078894 |
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NP_001157214
NP_001157215
NP_848507 |
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| Location (UCSC) | Chr 11: 119.17 – 119.18 Mb | Chr 9: 44.25 – 44.27 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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FunctionEditNLRX1 is an intracellular protein that plays a role in the immune system. NLRX1 has been proposed to affect innate immunity to viruses by interfering with the mitochondrial antiviral signaling protein (MAVS)/retinoic-acid-inducible gene I (RIG-I) mitochondrial antiviral pathway.,[7] although this was recently questioned.[8][9]
NLRX1 also plays a role in host immunity during bacterial infections, such as Chlamydia trachomatis and Helicobacter pylori, by regulating bacterial burden and inflammation in mononuclear phagocytes. Mechanisms underlying the modulation of NLRX1 are not well characterized, however computational modeling predictions suggest that levels of NLRX1 may be controlled by negative feedback circuits induced early after infection.[10][11][12]
