NLRP7

 NACHT, LRR and PYD domains-containing protein 7 is a protein that in humans is encoded by the NLRP7 gene.^[3][4][5]

NLRP7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2KM6
Identifiers
Aliases	NLRP7, CLR19.4, HYDM, NALP7, NOD12, PAN7, PYPAF3, NLR family, pyrin domain containing 7, NLR family pyrin domain containing 7
External IDs	OMIM: 609661 HomoloGene: 51401 GeneCards: NLRP7
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 54,923,509 bp[1] End 54,966,312 bp[1]
Gene ontology Molecular function • ATP binding • nucleotide binding • aspartic-type endopeptidase inhibitor activity • interleukin-1 binding • caspase binding Cellular component • cellular component Biological process • negative regulation of endopeptidase activity • negative regulation of protein processing • cellular response to lipopolysaccharide • cellular response to interleukin-1 • negative regulation of cytokine production involved in inflammatory response • negative regulation of aspartic-type peptidase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	199713	n/a
Ensembl	ENSG00000276804 ENSG00000167634 ENSG00000278173 ENSG00000277179 ENSG00000274174 ENSG00000277776 ENSG00000277786 ENSG00000275483 ENSG00000277071 ENSG00000274571	n/a
UniProt	Q8WX94	n/a
RefSeq (mRNA)	NM_001127255 NM_139176 NM_206828	n/a
RefSeq (protein)	NP_001120727 NP_631915 NP_996611	n/a
Location (UCSC)	Chr 19: 54.92 – 54.97 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

FunctionEdit

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP7, have an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.^[5]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.