NLRP6

 NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.^[5]

NLRP6
Identifiers
Aliases	NLRP6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NLR family, pyrin domain containing 6, NLR family pyrin domain containing 6
External IDs	OMIM: 609650 MGI: 2141990 HomoloGene: 15881 GeneCards: NLRP6
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 278,365 bp[1] End 285,359 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 140,920,902 bp[2] End 140,929,192 bp[2]
Gene ontology Molecular function • nucleotide binding • vasopressin receptor activity • ATP binding Cellular component • cytoplasm • not the membrane • membrane • cell membrane • inflammasome • cell nucleus Biological process • response to bacterium • immune system process • wound healing • regulation of mucus secretion • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of immune response • regulation of autophagy • negative regulation of toll-like receptor signaling pathway • negative regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of MAPK cascade • negative regulation of ERK1 and ERK2 cascade • innate immune system • inflammatory response • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	171389	101613
Ensembl	ENSG00000174885	ENSMUSG00000038745
UniProt	P59044	Q91WS2
RefSeq (mRNA)	NM_001276700 NM_138329	NM_001081389 NM_133946
RefSeq (protein)	NP_001263629 NP_612202	NP_598707
Location (UCSC)	Chr 11: 0.28 – 0.29 Mb	Chr 7: 140.92 – 140.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.