NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.[5][6] NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.
| NLRP5 |
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| Identifiers |
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| Aliases | NLRP5, CLR19.8, MATER, NALP5, PAN11, PYPAF8, NLR family, pyrin domain containing 5, NLR family pyrin domain containing 5 |
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| External IDs | OMIM: 609658 MGI: 1345193 HomoloGene: 65105 GeneCards: NLRP5 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 19 (human)[1] |
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| | Band | 19q13.43 | Start | 55,999,726 bp[1] |
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| End | 56,061,810 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse)[2] |
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| | Band | 7 A3|7 10.22 cM | Start | 23,385,889 bp[2] |
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| End | 23,441,922 bp[2] |
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| Gene ontology |
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| Molecular function | • nucleotide binding
• ATP binding
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| Cellular component | • cytoplasm
• nucleolus
• mitochondrion
• cell nucleus
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| Biological process | • neuron death
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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NM_001039143
NM_011860
NM_001305857 |
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| RefSeq (protein) | | |
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NP_001034232
NP_001292786
NP_035990 |
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| Location (UCSC) | Chr 19: 56 – 56.06 Mb | Chr 7: 23.39 – 23.44 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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In humans, the NLRP5 protein is encoded by the NLRP5 gene.[7][8][9]
