NLRP4

 NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.^[5][6][7]

NLRP4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EWI
Identifiers
Aliases	NLRP4, CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2, NLR family, pyrin domain containing 4, NLR family pyrin domain containing 4
External IDs	OMIM: 609645 MGI: 1890518 HomoloGene: 75315 GeneCards: NLRP4
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.43 Start 55,836,540 bp[1] End 55,881,855 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 6,045,161 bp[2] End 6,105,150 bp[2]
Gene ontology Molecular function • nucleotide binding • ATP binding Cellular component • cytosol Biological process • inflammatory response • regulation of type I interferon production Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	147945	83564
Ensembl	ENSG00000160505	ENSMUSG00000034690
UniProt	Q96MN2	Q3TKR3
RefSeq (mRNA)	NM_134444	NM_031389
RefSeq (protein)	NP_604393	NP_113566
Location (UCSC)	Chr 19: 55.84 – 55.88 Mb	Chr 7: 6.05 – 6.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region.

The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]^[7]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.