NACHT, LRR and PYD domains-containing protein 12 is a protein that in humans is encoded by the NLRP12 gene.[4][5][6]
| NLRP12 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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2L6A, 4XHS |
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| Identifiers |
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| Aliases | NLRP12, CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2, NLR family, pyrin domain containing 12, NLR family pyrin domain containing 12 |
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| External IDs | OMIM: 609648 MGI: 2676630 HomoloGene: 16972 GeneCards: NLRP12 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 19 (human)[1] |
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| | Band | 19q13.42 | Start | 53,793,603 bp[1] |
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| End | 53,824,394 bp[1] |
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| Gene ontology |
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| Molecular function | • nucleotide binding
• cysteine-type endopeptidase activator activity involved in apoptotic process
• ATP binding
• GO:0001948 protein binding
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| Cellular component | • cytoplasm
• cell nucleus
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| Biological process | • dendritic cell migration
• regulation of cysteine-type endopeptidase activity involved in apoptotic process
• regulation of I-kappaB kinase/NF-kappaB signaling
• activation of cysteine-type endopeptidase activity involved in apoptotic process
• negative regulation of Toll signaling pathway
• signal transduction
• negative regulation of NIK/NF-kappaB signaling
• negative regulation of inflammatory response
• cellular response to cytokine stimulus
• negative regulation of I-kappaB kinase/NF-kappaB signaling
• positive regulation of inflammatory response
• negative regulation of protein autophosphorylation
• positive regulation of MHC class I biosynthetic process
• negative regulation of ERK1 and ERK2 cascade
• negative regulation of cytokine secretion
• negative regulation of NF-kappaB transcription factor activity
• negative regulation of signal transduction
• positive regulation of NIK/NF-kappaB signaling
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001277126
NM_001277129
NM_033297
NM_144687 |
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| RefSeq (protein) | |
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NP_001264055
NP_001264058
NP_653288 |
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| Location (UCSC) | Chr 19: 53.79 – 53.82 Mb | n/a |
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| PubMed search | [2] | [3] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM][6]
