NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response. NLRP8 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.[5][6]
| NLRP10 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | NLRP10, CLR11.1, NALP10, NOD8, PAN5, PYNOD, NLR family, pyrin domain containing 10, NLR family pyrin domain containing 10 |
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| External IDs | OMIM: 609662 MGI: 2444084 HomoloGene: 18468 GeneCards: NLRP10 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 11 (human)[1] |
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| | Band | 11p15.4 | Start | 7,957,537 bp[1] |
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| End | 7,965,426 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse)[2] |
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| | Band | 7|7 E3 | Start | 108,921,852 bp[2] |
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| End | 108,930,178 bp[2] |
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| Gene ontology |
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| Molecular function | • nucleotide binding
• ATP binding
• GTPase activity
• ATPase activity
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| Cellular component | • cell membrane
• extrinsic component of plasma membrane
• membrane
• cytoplasm
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| Biological process | • innate immune system
• adaptive immune response
• defense response to Gram-negative bacterium
• immune system process
• positive regulation of T-helper 17 type immune response
• defense response to fungus
• positive regulation of T-helper 1 type immune response
• positive regulation of inflammatory response
• positive regulation of defense response to bacterium
• inflammatory response
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | |
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ENSG00000276780
ENSG00000281166
ENSG00000182261 |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 11: 7.96 – 7.97 Mb | Chr 7: 108.92 – 108.93 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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