NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity.[5][6][7]
| NLRC5 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | NLRC5, CLR16.1, NOD27, NOD4, NLR family, CARD domain containing 5, NLR family CARD domain containing 5 |
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| External IDs | OMIM: 613537 MGI: 3612191 HomoloGene: 88935 GeneCards: NLRC5 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 16 (human)[1] |
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| | Band | 16q13 | Start | 56,989,485 bp[1] |
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| End | 57,083,531 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 8 (mouse)[2] |
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| | Band | 8|8 C5 | Start | 94,434,356 bp[2] |
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| End | 94,527,272 bp[2] |
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| Gene ontology |
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| Molecular function | • nucleotide binding
• GO:0001948 protein binding
• ATP binding
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
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| Cellular component | • cytoplasm
• centrosome
• cell nucleus
• cytosol
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| Biological process | • positive regulation of type I interferon-mediated signaling pathway
• negative regulation of type I interferon production
• positive regulation of interferon-gamma-mediated signaling pathway
• positive regulation of MHC class I biosynthetic process
• positive regulation of transcription from RNA polymerase II promoter
• regulation of kinase activity
• immune system process
• innate immune system
• negative regulation of NF-kappaB transcription factor activity
• negative regulation of type I interferon-mediated signaling pathway
• response to bacterium
• GO:0007243 intracellular signal transduction
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 16: 56.99 – 57.08 Mb | Chr 8: 94.43 – 94.53 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Recently, NLRC5 has been suggested to play a positive role in the regulation of Major Histocompatibility Class I (MHCI) molecule expression.[8] This aspect of NLRC5 function was further investigated with the help of Nlrc5-deficient mice, which showed reduced MHCI expression in lymphocytes (particularly T, NK and NKT lymphocytes).[9] In lymphocytes, NLRC5 localizes to the nucleus and drives MHCI gene expression by occupying H-2D and H-2K gene promoters.[9]
In humans, the NLRC5 protein is encoded by the NLRC5 gene.[10] It has also been called NOD27, NOD4, and CLR16.1.
