Netrin-1 is a protein that in humans is encoded by the NTN1 gene.[5][6]
| NTN1 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| Identifiers |
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| Aliases | NTN1, NTN1L, netrin 1, MRMV4 |
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| External IDs | OMIM: 601614 MGI: 105088 HomoloGene: 21008 GeneCards: NTN1 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 17 (human)[1] |
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| | Band | 17p13.1 | Start | 9,021,510 bp[1] |
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| End | 9,244,000 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 11 (mouse)[2] |
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| | Band | 11|11 B3 | Start | 68,209,364 bp[2] |
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| End | 68,400,823 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • GO:0001948 protein binding
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| Cellular component | • extracellular region
• cytoplasm
• basement membrane
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| Biological process | • mammary gland duct morphogenesis
• positive regulation of cell motility
• axon guidance
• substrate-dependent cell migration, cell extension
• Cdc42 protein signal transduction
• positive regulation of axon extension
• inner ear morphogenesis
• negative regulation of axon extension
• apoptotic process
• mammary gland development
• positive regulation of cell proliferation
• regulation of cell migration
• Ras protein signal transduction
• anterior/posterior axon guidance
• neuron migration
• axonogenesis
• nuclear migration
• cell-cell adhesion
• negative regulation of netrin-activated signaling pathway
• regulation of synapse assembly
• chemorepulsion of axon
• motor neuron axon guidance
• animal organ morphogenesis
• histogenesis
• dendrite development
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 17: 9.02 – 9.24 Mb | Chr 11: 68.21 – 68.4 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.[6]
InteractionsEditNTN1 has been shown to interact with Deleted in Colorectal Cancer.[5][7]
