NDEL1

 Nuclear distribution protein nudE-like 1 is a protein that in humans is encoded by the NDEL1 gene.^[5][6][7]

NDEL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V66
Identifiers
Aliases	NDEL1, EOPA, MITAP1, NDE1L1, NDE2, NUDEL, nudE neurodevelopment protein 1 like 1
External IDs	OMIM: 607538 MGI: 1932915 HomoloGene: 32567 GeneCards: NDEL1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 8,413,131 bp[1] End 8,490,411 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 68,821,434 bp[2] End 68,871,858 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • alpha-tubulin binding • GO:0001948 protein binding • beta-tubulin binding • oligopeptidase activity • microtubule binding • identical protein binding • GO:0032403 macromolecular complex binding Cellular component • cytoplasm • cell body • condensed chromosome kinetochore • neurofilament cytoskeleton • nuclear envelope • synaptic vesicle • spindle • chromosome • microtubule organizing center • microtubule associated complex • axon • cell leading edge • axon hillock • microtubules • chromosome, centromeric region • cytoskeleton • kinetochore • axon cytoplasm • cytosol • central region of growth cone • centrosome • kinesin complex Biological process • retrograde axonal transport • cell differentiation • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • chromosome segregation • neuron migration • positive regulation of axon regeneration • nervous system development • proteolysis • neuron projection extension • inner cell mass cell proliferation • multicellular organism development • regulation of intracellular protein transport • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • nuclear envelope disassembly • positive regulation of axon extension • neurofilament cytoskeleton organization • cerebral cortex radially oriented cell migration • neuron projection development • microtubule cytoskeleton organization • central nervous system neuron axonogenesis • regulation of microtubule motor activity • insulin receptor signaling pathway • establishment of mitotic spindle orientation • microtubule nucleation • mitotic centrosome separation • regulation of neuron projection development • cell migration • vesicle transport along microtubule • establishment of chromosome localization • centrosome localization • lysosome localization • positive regulation of ruffle assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81565	83431
Ensembl	ENSG00000166579	ENSMUSG00000018736
UniProt	Q9GZM8	Q9ERR1
RefSeq (mRNA)	NM_001025579 NM_030808 NM_001330129	NM_023668 NM_001363304 NM_001363305
RefSeq (protein)	NP_001020750 NP_001317058 NP_110435	NP_076157 NP_001350233 NP_001350234
Location (UCSC)	Chr 17: 8.41 – 8.49 Mb	Chr 11: 68.82 – 68.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a thiol-activated oligopeptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]

InteractionsEdit

NDEL1 has been shown to interact with Cyclin-dependent kinase 5,^[5] YWHAE,^[8] PAFAH1B1^[5][8] and DISC1.^[9][10]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.