Lens fiber major intrinsic protein is a protein that in humans is encoded by the MIP gene.[5][6][7]
| MIP |
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| Identifiers |
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| Aliases | MIP, AQP0, CTRCT15, LIM1, MIP26, MP26, major intrinsic protein of lens fiber |
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| External IDs | OMIM: 154050 MGI: 96990 HomoloGene: 40627 GeneCards: MIP |
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| Gene location (Human) |
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 | | Chr. | Chromosome 12 (human)[1] |
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| | Band | 12q13.3 | Start | 56,449,502 bp[1] |
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| End | 56,469,166 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 10 (mouse)[2] |
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| | Band | 10 D3|10 76.49 cM | Start | 128,225,838 bp[2] |
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| End | 128,231,812 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • calmodulin binding
• structural constituent of eye lens
• water channel activity
• channel activity
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| Cellular component | • integral component of membrane
• membrane
• cell membrane
• cell junction
• apical plasma membrane
• endoplasmic reticulum
• gap junction
• integral component of plasma membrane
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| Biological process | • response to stimulus
• water transport
• ion transmembrane transport
• lens development in camera-type eye
• protein homotetramerization
• visual perception
• positive regulation of cell adhesion
• gap junction-mediated intercellular transport
• transmembrane transport
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 12: 56.45 – 56.47 Mb | Chr 10: 128.23 – 128.23 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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FunctionEditMajor intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.[7]
