Lecithin–cholesterol acyltransferase

 Lecithin–cholesterol acyltransferase (LCAT, also called phosphatidylcholine–sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) (alpha-LCAT) and LDLs (beta-LCAT) in the blood plasma.^[5] LCAT deficiency can cause impaired vision due to cholesterol corneal opacities, anemia, and kidney damage.^[6] It belongs to the family of phospholipid:diacylglycerol acyltransferases.

LCAT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4X96, 4XWG, 4XX1, 5BV7
Identifiers
Aliases	LCAT, entrez:3931, lecithin-cholesterol acyltransferase
External IDs	OMIM: 606967 MGI: 96755 HomoloGene: 68042 GeneCards: LCAT
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 67,939,750 bp[1] End 67,944,131 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.06 cM Start 105,939,551 bp[2] End 105,943,382 bp[2]
Gene ontology Molecular function • transferase activity • O-acyltransferase activity • apolipoprotein A-I binding • GO:0001948 protein binding • transferase activity, transferring acyl groups • phosphatidylcholine-sterol O-acyltransferase activity Cellular component • extracellular region • high-density lipoprotein particle • extracellular exosome • extracellular Biological process • steroid metabolic process • regulation of high-density lipoprotein particle assembly • lipid metabolism • cholesterol transport • cholesterol metabolic process • cholesterol esterification • very-low-density lipoprotein particle remodeling • phospholipid metabolic process • lipoprotein biosynthetic process • cholesterol homeostasis • phosphatidylcholine biosynthetic process • phosphatidylcholine metabolic process • reverse cholesterol transport • high-density lipoprotein particle remodeling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3931	16816
Ensembl	ENSG00000213398	ENSMUSG00000035237
UniProt	P04180	P16301
RefSeq (mRNA)	NM_000229	NM_008490
RefSeq (protein)	NP_000220	NP_032516
Location (UCSC)	Chr 16: 67.94 – 67.94 Mb	Chr 8: 105.94 – 105.94 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactive pathway mapEdit

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|px|alt=Statin Pathway edit]]

Statin Pathway edit

1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.