Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan, is a protein that in humans is encoded by the KERA gene.[5][6][7]
| KERA |
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| Identifiers |
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| Aliases | KERA, CNA2, KTN, SLRR2B, keratocan |
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| External IDs | OMIM: 603288 MGI: 1202398 HomoloGene: 5106 GeneCards: KERA |
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| Gene location (Human) |
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 | | Chr. | Chromosome 12 (human)[1] |
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| | Band | 12q21.33 | Start | 91,050,491 bp[1] |
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| End | 91,057,983 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 10 (mouse)[2] |
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| | Band | 10 C3|10 50.34 cM | Start | 97,606,879 bp[2] |
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| End | 97,613,692 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • molecular function
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| Cellular component | • Golgi lumen
• extracellular region
• lysosomal lumen
• extracellular
• extracellular matrix
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| Biological process | • cornea development in camera-type eye
• keratan sulfate biosynthetic process
• keratan sulfate catabolic process
• axonogenesis
• response to stimulus
• visual perception
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 12: 91.05 – 91.06 Mb | Chr 10: 97.61 – 97.61 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.[7]
Mutations of the gene cause cornea plana 2.
