IRAK1

 Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene.^[5][6]

IRAK1
Identifiers
Aliases	IRAK1, IRAK, pelle, interleukin 1 receptor associated kinase 1
External IDs	OMIM: 300283 MGI: 107420 HomoloGene: 37496 GeneCards: IRAK1
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,010,506 bp[1] End 154,019,902 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 37.61 cM Start 74,013,914 bp[2] End 74,023,918 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • heat shock protein binding • protein homodimerization activity • kinase activity • NF-kappaB-inducing kinase activity • GO:0001948 protein binding • protein heterodimerization activity • ATP binding • protein serine/threonine kinase activity Cellular component • membrane • lipid droplet • cell membrane • endosome membrane • interleukin-1 receptor complex • cell nucleus • cytoplasm • cytosol Biological process • cellular response to heat • response to interleukin-1 • positive regulation of MAP kinase activity • regulation of cytokine-mediated signaling pathway • phosphorylation • cytokine-mediated signaling pathway • immune system process • aging • negative regulation of apoptotic process • activation of NF-kappaB-inducing kinase activity • MyD88-dependent toll-like receptor signaling pathway • toll-like receptor signaling pathway • positive regulation of transcription, DNA-templated • protein phosphorylation • JNK cascade • response to lipopolysaccharide • transmembrane receptor protein serine/threonine kinase signaling pathway • activation of MAPK activity • positive regulation of NF-kappaB transcription factor activity • protein oligomerization • positive regulation of I-kappaB kinase/NF-kappaB signaling • autophosphorylation • toll-like receptor 9 signaling pathway • cellular response to lipopolysaccharide • negative regulation of NF-kappaB transcription factor activity • nucleotide-binding oligomerization domain containing signaling pathway • positive regulation of type I interferon production • cellular response to hypoxia • lipopolysaccharide-mediated signaling pathway • signal transduction • positive regulation of smooth muscle cell proliferation • toll-like receptor 4 signaling pathway • toll-like receptor 2 signaling pathway • innate immune system • type I interferon signaling pathway • GO:0022415 viral process • interleukin-1-mediated signaling pathway • GO:0007243 intracellular signal transduction • positive regulation of NIK/NF-kappaB signaling • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3654	16179
Ensembl	ENSG00000184216	ENSMUSG00000031392
UniProt	P51617	Q62406
RefSeq (mRNA)	NM_001025242 NM_001025243 NM_001569	NM_001177973 NM_001177974 NM_001177975 NM_001177976 NM_008363
RefSeq (protein)	NP_001020413 NP_001020414 NP_001560	NP_001171444 NP_001171445 NP_001171446 NP_001171447 NP_032389
Location (UCSC)	Chr X: 154.01 – 154.02 Mb	Chr X: 74.01 – 74.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[7]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

InteractionsEdit

IRAK1 has been shown to interact with:

• CHUK^[8][9]
• IKBKG^[8][10]
• IKK2,^[8][9]
• Myd88^{[11][12][13][14]}
• NEMO^[15]
• SOCS1^[15]
• STAT3^[15]
• TRAF6^{[12][13][16][17][18][19][20][21][22]}
• UBC,^{[8][10][23][24]}
• TOLLIP^[25]
• TLR4^[26]

Clinical significanceEdit

IRAK1 signaling is involved in rheumatoid arthritis.^[27]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.