HRK (gene)

 Activator of apoptosis harakiri is a protein that in humans is encoded by the HRK gene.^[3][4]

HRK
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2L58, 2L5B
Identifiers
Aliases	HRK, DP5, HARAKIRI, harakiri, BCL2 interacting protein
External IDs	OMIM: 603447 HomoloGene: 136405 GeneCards: HRK
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.22 Start 116,856,144 bp[1] End 116,881,441 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • membrane • mitochondrion Biological process • regulation of apoptotic process • positive regulation of protein homooligomerization • positive regulation of release of cytochrome c from mitochondria • positive regulation of apoptotic process • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8739	n/a
Ensembl	ENSG00000135116	n/a
UniProt	O00198	n/a
RefSeq (mRNA)	NM_003806	n/a
RefSeq (protein)	NP_003797	n/a
Location (UCSC)	Chr 12: 116.86 – 116.88 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

FunctionEdit

Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL.^[4]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.