HOXB7

 Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.^[5][6]

HOXB7
Identifiers
Aliases	HOXB7, HHO.C1, HOX2, HOX2C, Hox-2.3, homeobox B7
External IDs	OMIM: 142962 MGI: 96188 HomoloGene: 55828 GeneCards: HOXB7
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 48,607,232 bp[1] End 48,633,572 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 59.82 cM Start 96,286,623 bp[2] End 96,290,162 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • DNA binding • GO:0001948 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • cell nucleus • nucleoplasm • cytosol • nuclear body Biological process • multicellular organism development • embryonic skeletal system morphogenesis • myeloid cell differentiation • positive regulation of branching involved in ureteric bud morphogenesis • regulation of transcription, DNA-templated • transcription, DNA-templated • anterior/posterior pattern specification • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3217	15415
Ensembl	ENSG00000260027	ENSMUSG00000038721
UniProt	P09629	P09024
RefSeq (mRNA)	NM_004502	NM_010460
RefSeq (protein)	NP_004493	NP_034590
Location (UCSC)	Chr 17: 48.61 – 48.63 Mb	Chr 11: 96.29 – 96.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FunctionEdit

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.^[7]

InteractionsEdit

HOXB7 has been shown to interact with PBX1^[8] and CREB-binding protein.^[9]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.