Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans.[5]
| GABBR2 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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4F11, 4F12, 4MQE, 4MQF, 4MR7, 4MR8, 4MR9, 4MRM, 4MS1, 4MS3, 4MS4, 4PAS |
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| Identifiers |
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| Aliases | GABBR2, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, gamma-aminobutyric acid type B receptor subunit 2, EIEE59, NDPLHS |
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| External IDs | OMIM: 607340 MGI: 2386030 HomoloGene: 55902 GeneCards: GABBR2 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 9 (human)[1] |
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| | Band | 9q22.33 | Start | 98,288,109 bp[1] |
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| End | 98,708,935 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 4 (mouse)[2] |
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| | Band | 4|4 B1 | Start | 46,662,305 bp[2] |
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| End | 46,991,873 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • GO:0001948 protein binding
• G-protein coupled receptor activity
• G-protein coupled GABA receptor activity
• signal transducer activity
• protein heterodimerization activity
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| Cellular component | • cytoplasm
• integral component of membrane
• neuron projection
• cell junction
• G-protein coupled receptor heterodimeric complex
• cell membrane
• postsynaptic membrane
• synapse
• integral component of plasma membrane
• membrane
• GABA receptor complex
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| Biological process | • gamma-aminobutyric acid signaling pathway
• G-protein coupled receptor signaling pathway
• negative regulation of adenylate cyclase activity
• signal transduction
• chemical synaptic transmission
• neuron-glial cell signaling
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 9: 98.29 – 98.71 Mb | Chr 4: 46.66 – 46.99 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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FunctionEditB-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM][5]
InteractionsEditGABBR2 has been shown to interact with GABBR1.[6]
