Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.[5][6][7]
| FOLR2 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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4KMY, 4KMZ, 4KN0, 4KN1, 4KN2 |
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| Identifiers |
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| Aliases | FOLR2, BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, FRbeta, FOLR1 |
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| External IDs | OMIM: 136425 MGI: 95569 HomoloGene: 627 GeneCards: FOLR2 |
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| Gene location (Human) |
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 | | Chr. | Chromosome 11 (human)[1] |
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| | Band | 11q13.4 | Start | 72,216,601 bp[1] |
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| End | 72,221,950 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 7 (mouse)[2] |
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| | Band | 7|7 E2 | Start | 101,839,988 bp[2] |
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| End | 101,857,194 bp[2] |
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| RNA expression pattern |
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 | | More reference expression data |
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| Gene ontology |
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| Molecular function | • methotrexate binding
• drug binding
• folic acid binding
• folic acid receptor activity
• signaling receptor activity
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| Cellular component | • cell surface
• anchored component of membrane
• anchored component of external side of plasma membrane
• membrane
• extracellular region
• cell membrane
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| Biological process | • regulation of thymidylate synthase biosynthetic process
• inflammatory response
• receptor-mediated endocytosis
• positive regulation of cell proliferation
• monocyte chemotaxis
• cellular response to folic acid
• folic acid metabolic process
• folic acid transport
• folic acid import across plasma membrane
• cell adhesion
• fusion of sperm to egg plasma membrane involved in single fertilization
• sperm-egg recognition
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| Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_000803
NM_001113534
NM_001113535
NM_001113536 |
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NM_008035
NM_001303231
NM_001303239 |
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| RefSeq (protein) | |
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NP_000794
NP_001107006
NP_001107007
NP_001107008 |
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NP_001290160
NP_001290168
NP_032061 |
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| Location (UCSC) | Chr 11: 72.22 – 72.22 Mb | Chr 7: 101.84 – 101.86 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.[7]
