EEA1

 The gene EEA1 encodes for the 1400 amino acid protein, Early Endosome Antigen 1.

EEA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HYI, 1HYJ, 1JOC, 3MJH
Identifiers
Aliases	EEA1, MST105, MSTP105, ZFYVE2, early endosome antigen 1
External IDs	OMIM: 605070 MGI: 2442192 HomoloGene: 37822 GeneCards: EEA1
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q22 Start 92,770,637 bp[1] End 92,929,331 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C2 Start 95,940,650 bp[2] End 96,045,518 bp[2]
Gene ontology Molecular function • protein homodimerization activity • zinc ion binding • metal ion binding • calmodulin binding • GTP-dependent protein binding • 1-phosphatidylinositol binding • GO:0001948 protein binding • nucleic acid binding Cellular component • cytoplasm • recycling endosome • cytosol • endosome • early endosome membrane • membrane • axonal spine • serine-pyruvate aminotransferase complex • early endosome • extrinsic component of plasma membrane • extracellular exosome • cytoplasmic vesicle • presynapse • synapse Biological process • endocytosis • early endosome to late endosome transport • synaptic vesicle to endosome fusion • vesicle fusion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8411	216238
Ensembl	ENSG00000102189	ENSMUSG00000036499
UniProt	Q15075	Q8BL66
RefSeq (mRNA)	NM_003566	NM_001001932
RefSeq (protein)	NP_003557	NP_001001932
Location (UCSC)	Chr 12: 92.77 – 92.93 Mb	Chr 10: 95.94 – 96.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

EEA1 localizes exclusively to early endosomes and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate through its C-terminal FYVE domain and forms a homodimer through a coiled coil. EEA1 acts as a tethering molecule that couples vesicle docking with SNAREs such as N-ethylmaleimide sensitive fusion protein, bringing the endosomes physically closer and ultimately resulting in the fusion and delivery of endosomal cargo.

FunctionEdit

EEA1 is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is required for fusion of early and late endosomes and for sorting at the early endosome level.^[5][6]

Involvement in pathogenesisEdit

Due to the proteins importance in vesicular trafficking, a number of intracellular bacteria prevent EEA1 recruitment to the vacuole. Mycobacterium tuberculosis is known to inhibit the recruitment of EEA1 to the phagosomal membrane through CamKII.^[7] Legionella pneumophila also prevents EEA1 recruitment through a currently unknown mechanism.^[8] The related pathogen Legionella longbeachae recruits EEA1 and appears to replicate within a modified early endosome.^[9]

This article uses material from the Wikipedia article  Metasyntactic variable, which is released under the  Creative Commons Attribution-ShareAlike 3.0 Unported License.